Published March 1986
| Version v1
Journal article
Microscale synthesis of nitrogen-13-labeled cisplatin
Creators
- 1. State Univ. of Ghent, Belgium
Description
A microscale synthesis of [13N]cisplatin (cis-dichlorodiammineplatinum(II), cis-DDP) from cyclotron-produced [13N]ammonia is presented. Temperature, reaction time, ratios, and concentration of reactants have been optimized for each step of the synthesis. Purification is performed by ion exchange chromatography. Radiochemical purity and optimization processes are controlled by high performance liquid chromatography and high performance thin layer chromatography--22 mCi [13N]cisplatin in 10 ml of solution is produced. The entire procedure takes approximately 15 min and the specific activity is approximately 300 mCi/mumole at EOB
Additional details
Publishing Information
- Journal Title
- J. Nucl. Med.
- Journal Issue
- no.3
- Series
- J. Nucl. Med.
- ISSN
- 0022-3123
- CODEN
- JNMEA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18013853
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AMMONIA; ANTIMITOTIC DRUGS; LABELLING; NITROGEN 13; PURIFICATION; QUALITY CONTROL; RADIOCHEMISTRY; SYNTHESIS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMISTRY; CONTROL; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HYDRIDES; HYDROGEN COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NITROGEN COMPOUNDS; NITROGEN HYDRIDES; NITROGEN ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; POLAR SOLVENTS; RADIOISOTOPES; SOLVENTS