Published 1995 | Version v1
Report Open

Studies of the brain cannabinoid system using positron emission tomography

Creators

Description

Studies using radiolabeled psychoactive drugs in conjunction with positron emission tomography (PET) have permitted the imaging of binding sites in the human brain. Similar studies of marijuana have been hampered by the unsuitability of radiolabeled THC for PET studies, and the current unavailability of other in vivo imaging agents for cannabinoid receptors. Recent developments in medicinal chemistry suggest that a PET radiotracer for cannabinoid receptors will soon become available. This chapter briefly reviews these developments, together with the results of PET studies of the effects of marijuana and other abused drugs on brain metabolism. It also reviews PET studies of cocaine binding sites, to demonstrate the kind of investigations that will be possible when a cannabinoid receptor PET radioligand becomes available

Availability note (English)

MF available from INIS under the Report Number; Also available from OSTI as DE96000891; NTIS; US Govt. Printing Office Dep.

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Additional details

Publishing Information

Imprint Pagination
10 p.
Report number
BNL--62252

Conference

Title
Drug abuse in the decade of the brain.
Dates
22-23 Sep 1995.
Place
Houston, TX (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
27041241
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CARBON 11; CEREBRUM; DRUG ABUSE; FLUORINE 18; GLUCOSE; LABELLING; METABOLISM; PLANNING; POSITRON COMPUTED TOMOGRAPHY; PSYCHOTROPIC DRUGS; RADIOCHEMISTRY; RADIOPHARMACEUTICALS
Descriptors DEC
ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARBOHYDRATES; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; CHEMISTRY; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; MONOSACCHARIDES; NANOSEC LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SACCHARIDES; TOMOGRAPHY

Optional Information

Contract/Grant/Project number
Contract AC02-76CH00016; Grant 5R01-DA06891
Funding organization
USDOE, Washington, DC (United States); Department of Health and Human Services, Washington, DC (United States).
Secondary number(s)
CONF-9509278--1.