Published January 2002 | Version v1
Journal article Metadata-only

1H NMR and IR spectroscopic study of the structure of the major component of the 99mTc HMPAO (hexamethylpropylene-amino oxime) radiopharmaceutical preparation

Creators

  • 1. GUP Zavod Medradiopreparat, Moscow (Russian Federation)
  • 2. Inst. Ehlementoorganicheskikh Soedinenij im. A.N. Nesmeyanova RAN, Moscow (Russian Federation)

Description

Practicability of the PMR and IR spectroscopy methods for the development of a simple method permitting estimation of the content of meso-form of hexamethylpropyleneaminoxime (HMPAO) impurity in d,l-isomer of HMPAO contained in radiopharmaceutical preparations 99mTc HMPAO, was studied. The structure of HMPAO conformers in aqueous solution in the range of pH values of 1-12.5 was studied by the PMR method. A method for estimating the amount of meso-form in a mixture of isomers on the basis of the PMR spectra was suggested, optimal conditions for the analysis being ascertained. It is pointed out that specific features of HMPAO isomers IR spectra depend on their structure and differences in molecules packing in crystal lattice

Abstract (Russian)

Изучена возможность использования методов ПМР и ИК спектроскопии для разработки простого метода оценки содержания примеси мезо-формы гексаметилпропиленаминоксима (ГМПАО) в d,l-изомере ГМПАО, входящем в состав радиофармацевтического препарата 99mTc ГМПАО. Методом ПМР изучено строение конформеров ГМПАО в водном растворе в диапазоне значений рН 1-12,5. Предложен метод оценки количества мезо-формы в смеси изомеров на основе спектров ПМР и определены оптимальные условия анализа. Отмечено, что особенности ИК спектров изомеров ГМПАО зависят от их строения и различия в упаковке молекул в кристаллической решетке

Additional details

Additional titles

Original title (Russian)
Исследование строения основного компонента радиофармацевтического препарата

Publishing Information

Journal Title
Koordinatsionnaya Khimiya
Journal Volume
28
Journal Issue
1
Journal Page Range
p. 74-77
ISSN
0132-344X
CODEN
KOKHDC

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
34012472
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
ENANTIOMORPHS; INFRARED SPECTRA; NMR SPECTRA; OXIMES; PROTONS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOPHARMACEUTICALS; STRUCTURAL CHEMICAL ANALYSIS; TECHNETIUM 99
Descriptors DEC
AMINES; BARYONS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL ANALYSIS; DRUGS; ELEMENTARY PARTICLES; FERMIONS; HADRONS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOMERS; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; NUCLEONS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SPECTRA; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
6 refs.; 3 figs.