Published 1988
| Version v1
Journal article
Interaction between human platelet factor 4 and protamine sulfate in the presence of a low molecular weight heparin in the rabbit
- 1. Padua Univ. (Italy). II Cattedra di Medicina
- 2. Laboratori di Ricerca FIDIA, Abano Terme (Italy)
- 3. Harvard Medical School, Boston, MA (USA)
Description
The effects of different protamine sulfate (PS) doses (15, 30 and 50 mg) upon the kinetics of human platelet factor 4 (PF4) combined with a low molecular weight (LMW) heparin of 7,400 daltons in the rabbit have been studied. The PF4 disappearance after pre-treatment with 1500 APTT units of LMW heparin followed a monoexponential curve with an half-life of 11.03±1.69 minutes. PS at each dosage given 1 minute after LMW heparin and PF4, caused an immediate and deep drop of PF4 circulating level. A second LMW heparin bolus 10 minuts later induced in which 50 mg of PS were given, the PF4 release was only 40% of that obtained in the order two groups of animals
Additional details
Publishing Information
- Journal Title
- Journal of Nuclear Medicine and Allied Sciences
- Journal Volume
- 32
- Journal Issue
- 1
- Series
- J. Nucl. Med. Allied Sci.
- Journal Page Range
- 54-57
- CODEN
- JNMSD
INIS
- Country of Publication
- Italy
- Country of Input or Organization
- Italy
- INIS RN
- 20011946
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CARDIOVASCULAR DISEASES; CHEMICAL REACTIONS; HEPARIN; PROTAMINES; RADIOPHARMACEUTICALS; SULFATES
- Descriptors DEC
- AMINES; ANTICOAGULANTS; BLOOD COAGULATION FACTORS; CARBOHYDRATES; COAGULANTS; DISEASES; DRUGS; HEMATOLOGIC AGENTS; LABELLED COMPOUNDS; MATERIALS; MUCOPOLYSACCHARIDES; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; OXYGEN COMPOUNDS; POLYSACCHARIDES; PROTEINS; RADIOACTIVE MATERIALS; SACCHARIDES; SULFUR COMPOUNDS