Published November 1980 | Version v1
Journal article

Effect of exogenous DNA on colony-forming capacity and sub-population composition of irradiated mouse bone marrow

  • 1. Tsentral'nyj Nauchno-Issledovatel'skij Rentgeno-Radiologicheskij Inst., Leningrad (USSR)

Description

With short-term (30 min) combined incubation in vitro of DNA and bone-marrow cells of (C57B1xCBA)F1 mice a cytotoxic effect of the polymer was established according to vitality of cells, changes in their subpopulation composition and capacity to form splenic exocolonies. It was demonstrated that the cells of the erythroid series are the most sensitive to cytopathogenic effect of DNA. The effect is enhanced immediately after X-irradiation of bone marrow in situ in a dose of 8 Gy, the concentration of the DNA preparation in the suspension being increased and high polymeric fraction content elevated

Additional details

Additional titles

Original title (Russian)
Влияние экзогенной DNK на колониеобразующие свойства и субпопуляционный состав облученных клеток костного мозга мышей

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
20
Journal Issue
6
Series
Radiobiologiya.
Journal Page Range
850-854
ISSN
0033-8192

Optional Information

Notes
For English translation see the journal Radiobiology (USA).