Published March 1, 2011 | Version v1
Journal article

Dynamic model of gene regulation for the lac operon

  • 1. Intelligent Modelling Lab, School of Computing, Engineering and Information Sciences, Northumbria University, Newcastle upon Tyne NE2 1XE (United Kingdom)

Description

Gene regulatory network is a collection of DNA which interact with each other and with other matter in the cell. The lac operon is an example of a relatively simple genetic network and is one of the best-studied structures in the Escherichia coli bacteria. In this work we consider a deterministic model of the lac operon with a noise term, representing the stochastic nature of the regulation. The model is written in terms of a system of simultaneous first order differential equations with delays. We investigate an analytical and numerical solution and analyse the range of values for the parameters corresponding to a stable solution.

Availability note (English)

Available from http://dx.doi.org/10.1088/1742-6596/286/1/012007

Additional details

Publishing Information

Journal Title
Journal of Physics. Conference Series (Online)
Journal Volume
286
Journal Issue
1
Journal Page Range
[5 p.]
ISSN
1742-6596

Conference

Title
Condensed matter and materials physics conference
Acronym
CMMP10
Dates
14-16 Dec 2010
Place
Warwick (United Kingdom)

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
43042830
Subject category
S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ANALYTICAL SOLUTION; DIFFERENTIAL EQUATIONS; DNA; ESCHERICHIA COLI; GENE REGULATION; GENES; NOISE; NUMERICAL SOLUTION; REGULATIONS; STOCHASTIC PROCESSES
Descriptors DEC
BACTERIA; EQUATIONS; LAWS; MATHEMATICAL SOLUTIONS; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS