Published February 1993 | Version v1
Journal article Metadata-only

The effect of lysine-germanium on natural killer activity by 51Cr release assay

Creators

  • 1. Basic Medical School, Shanghai Second Medical Univ., Shanghai (China)
  • 2. Shanghai Immunology Institute, Shanghai (China)

Description

The effect of lysine-germanium (Ge401), a novel organo germanium on the natural killer activity (NK-A) in human peripheral blood was studied using 51Cr labelled K562 cells as target cells. Ge401(50, 100 and 200 μg/ml) could augment NK-A(%) from 24.30±6.05 of the control group to 32.52±6.07(p < 0.05), 39.70±7.38(p < 0.01) and 43.42±7.71(p < 0.001) respectively, showing obvious dose-dependence. However, there is no direct influence of Ge401(100 and 200 μg/ml) on 51Cr release rate of K562 leukemia cells

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
16
Journal Issue
2
Journal Page Range
p. 99-102.
ISSN
0253-3219
CODEN
NUTEDL

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
24056922
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
BIOLOGICAL EFFECTS; CELL KILLING; CELL PROLIFERATION; CHROMIUM 51; DOSE-RESPONSE RELATIONSHIPS; GERMANIUM COMPOUNDS; LYSINE; TUMOR CELLS
Descriptors DEC
AMINO ACIDS; ANIMAL CELLS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHROMIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES