Published November 2011 | Version v1
Report Metadata-only

Research of heavy ion radiotherapy based on formation of heterochromatin

Creators

  • 1. National Inst. of Radiological Sciences, Chiba, Chiba (Japan)

Description

We studied about mechanism of heavy ion radiotherapy based on formation of heterochromatin. Role of D-NHEJ or HRR pathway in the biological effect of heavy ion irradiation is not clear. XRCC4 is a core factor of D-NHEJ pathway. For the purpose of determining the role of D-NHEJ in the effect of heavy ion irradiation, we performed survival fraction assay using HCT116 XRCC4-/- cells. Surprisingly, linear energy transfer (LET) dependency of survival fraction assay of HCT116 XRCC4-/- cells lost clearly. Preliminary data of survival fraction assay using HCT116 XRCC4-/- rescued by XRCC4 plasmid showed recovery of LET dependency and interesting phenomenon. We are going to do further analysis in detail. (author)

Part of:
2010 annual report of the research project with heavy ions at NIRS-HIMAC

Additional details

Identifiers

URL
http://id.nii.ac.jp/1657/00073745/;

Publishing Information

Imprint Title
2009 annual report of the research project with heavy ions at NIRS-HIMAC
Imprint Pagination
322 p.
Journal Page Range
p. 141
Report number
NIRS-M--244

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
53067184
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Non-conventional Literature
Descriptors DEI
CARBON IONS; CELL FLOW SYSTEMS; CHO CELLS; GENETIC CONTROL; GENETIC RADIATION EFFECTS; HEAVY IONS; HETEROCHROMATIN; IRON IONS; LET; RADIOTHERAPY; SURVIVAL CURVES; TUMOR CELLS; X RADIATION
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CHARGED PARTICLES; CHROMATIN; CONTROL; ELECTROMAGNETIC RADIATION; ENERGY TRANSFER; GENETIC EFFECTS; IONIZING RADIATIONS; IONS; MEDICINE; NUCLEAR MEDICINE; PEST CONTROL; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; SOMATIC CELLS; THERAPY

Optional Information

Notes
This record replaces 45052117
Secondary number(s)
HIMAC--136