Published January 2010
| Version v1
Journal article
Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies
Creators
- 1. Technological Oncologyc Laboratory (LaTO), Contrada Pietrapollastra Pisciotto, 90015 Cefalu (Italy)
- 2. Institute of Molecular Bioimaging and Physiology-CNR, University of Milano-Bicocca, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano (Italy)
- 3. Comecer S.p.A., Via Emilia Ponente 390, 48014 Castelbolognese (Italy)
Description
60Cu and 64Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of 60/64Cu starting from 60/64Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of 60/64Ni/60/64Cu was developed. Preliminary production yields of 60Cu and 64Cu were 400 and 300 mCi, respectively. 64Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2±1.3 Ci/μmol.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.apradiso.2009.08.010Additional details
Identifiers
- DOI
- 10.1016/j.apradiso.2009.08.010;
- PII
- S0969-8043(09)00510-7;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 68
- Journal Issue
- 1
- Journal Page Range
- p. 5-13
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 41062533
- Subject category
- S07: ISOTOPES AND RADIATION SOURCES;
- Descriptors DEI
- COPPER 60; COPPER 64; DIAGNOSIS; DISSOLUTION; ELECTRODEPOSITION; NICKEL 64; POSITRON COMPUTED TOMOGRAPHY; PURIFICATION; RADIOPHARMACEUTICALS; RADIOTHERAPY
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; COPPER ISOTOPES; DEPOSITION; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTROLYSIS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVEN-EVEN NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; LYSIS; MATERIALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NICKEL ISOTOPES; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOLOGY; STABLE ISOTOPES; SURFACE COATING; THERAPY; TOMOGRAPHY
Optional Information
- Copyright
- Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.