Published March 2022
| Version v1
Journal article
Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis
- 1. Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins (United States)
- 2. Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora (United States)
- 3. Allander Biotechnologies, LLC, Aurora (United States)
Description
Recent studies reported therapeutic effects of Smad7 on oral mucositis in mice without compromising radiation therapy–induced cancer cell killing in neighboring oral cancer. This study aims to assess whether a Smad7-based biologic can treat oral mucositis in a clinically relevant setting by establishing an oral mucositis model in dogs and analyzing molecular targets.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.ijrobp.2021.09.039Additional details
Identifiers
- DOI
- 10.1016/j.ijrobp.2021.09.039;
- PII
- S0360301621028431;
Publishing Information
- Journal Title
- International Journal of Radiation Oncology, Biology and Physics
- Journal Volume
- 112
- Journal Issue
- 3
- Journal Page Range
- p. 759-770
- ISSN
- 0360-3016
- CODEN
- IOBPD3
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 53124607
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CELL KILLING; DOGS; MICE; NEOPLASMS; PROTEINS; RADIOTHERAPY
- Descriptors DEC
- ANIMALS; DISEASES; MAMMALS; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; RADIOLOGY; RODENTS; THERAPY; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2021 Elsevier Inc. All rights reserved.