Published March 1982
| Version v1
Journal article
Uptake of cytosine arabinoside (ara-C) by LSA lymphoma after irradiation in the stationary phase of growth
Description
An in vitro system was used to assess uptake of cytosine arabinoside by LSA ascites tumor cells growing in vivo. Changes in tumor uptake with aging after depopulation and perturbation of the cell population with 1,000 rad were studied. Both DNA synthesis and drug uptake were highest during early rapid tumor growth and decreased with aging and the stationary phase of growth. However, irradiation caused a second peak of cellular activity and drug uptake. These results indicate that irradiation stimulates regrowth of tumor
Additional details
Publishing Information
- Journal Title
- Radiology
- Journal Volume
- 142
- Journal Issue
- 3
- Series
- Radiology.
- Journal Page Range
- 759-763
- ISSN
- 0033-8419
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 14731700
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANTIMETABOLITES; ASCITES TUMOR CELLS; BIOLOGICAL RADIATION EFFECTS; BIOSYNTHESIS; CELL KILLING; COBALT 60; COLONY FORMATION; DNA; GAMMA RADIATION; IN VITRO; KINETICS; MICE; RADIATION EFFECTS; RADIOBIOLOGY; RADIOSENSITIVITY
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGY; COBALT ISOTOPES; DRUGS; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIATIONS; RADIOISOTOPES; RODENTS; SYNTHESIS; TUMOR CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES