Published 1990 | Version v1
Report Metadata-only

Radiosynthesis of [O-methyl-11C]viqualine through an N-trityl protected intermediate for evaluation as a PET radioligand for 5-HT re-uptake sites

Creators

  • 1. Hammersmith Hospital, London (England)

Description

The isoquinoline derivative, viqualine, is a potent inhibitor of 5-HT re-uptake. The authors have considered that the labelling of viqualine with carbon-11 might provide a radioligand for PET studies of 5-HT sites. They have developed a method for the labelling process and conducted a biological evaluation of the [O-methyl-11C]viqualine thus produced in rats

Additional details

Publishing Information

Imprint Title
Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
Imprint Pagination
458 p.
Journal Page Range
p. 400-401.
Report number
DOE/ER/60968--1

Conference

Title
8. international symposium on radiopharmaceutical chemistry.
Dates
24-29 Jun 1990.
Place
Princeton, NJ (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
23029830
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
AMINES; BRAIN; CARBON 11; CHEMICAL PREPARATION; IN VIVO; LABELLING; LIQUID COLUMN CHROMATOGRAPHY; MASS SPECTRA; METHYL IODIDE; METHYLATION; MOLECULAR STRUCTURE; NMR SPECTRA; RADIOPHARMACEUTICALS; RATS; RECEPTORS; SEROTONIN; SILICA GEL; THALAMUS; THIN-LAYER CHROMATOGRAPHY; TISSUE DISTRIBUTION; TRITIUM; UPTAKE
Descriptors DEC
ADSORBENTS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; CHEMICAL REACTIONS; CHROMATOGRAPHY; DISTRIBUTION; DRUGS; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; INDOLES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRROLES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; SEPARATION PROCESSES; SPECTRA; SYMPATHOMIMETICS; SYNTHESIS; TRYPTAMINES; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Secondary number(s)
CONF-9006363--Absts.