Antioxidant activity of caffeic acid-derived polymer from Anchusa italica
- 1. I.Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, Tbilisi (Georgia)
Description
The main chemical constituent of high-molecular water-soluble preparations from Symphytum asperum, S. caucasicum, S.officinale and Anchusa italica was found to be a caffeic acid-derived polyether, namely poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDPGA). In contrast to Symphytum polymer, most of the carboxylic groups of polymer from A. italica are methylated. PDPGA of different species of Symphytum revealed pronounced anticomplementary, antioxidant, anti-inflammatory and wound healing activities. Comparative study of antioxidant activity of PDPGA from A. italica with its synthetic monomer racemic 3-(3,4-dihydroxyphenyl)glyceric acid and trans-caffeic acid against the relatively stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical was investigated. IC50 value of PDPGA-AI is 51.5 μg/ml. (author)
Additional details
Publishing Information
- Journal Title
- Bulletin of the Georgian National Academy of Sciences
- Journal Volume
- 11
- Journal Issue
- 2
- Journal Page Range
- p. 123-127
- ISSN
- 0132-1447
INIS
- Country of Publication
- Georgia
- Country of Input or Organization
- Georgia
- INIS RN
- 52072871
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ANTIOXIDANTS; COST; DATA; DPPH; ECONOMICS; GLYCERIC ACID; HEALING; INFLAMMATION; MONOMERS; POLYETHYLENE GLYCOLS; RACEMATES; SOCIO-ECONOMIC FACTORS; WATER; WOUNDS
- Descriptors DEC
- ALCOHOLS; BIOLOGICAL RECOVERY; CARBOXYLIC ACIDS; DISEASES; ETHYLENE GLYCOLS; GLYCOLS; HYDROGEN COMPOUNDS; HYDROXY ACIDS; HYDROXY COMPOUNDS; INFORMATION; INJURIES; INSTITUTIONAL FACTORS; NITRO COMPOUNDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC POLYMERS; OXYGEN COMPOUNDS; PATHOLOGICAL CHANGES; POLYMERS; RADICALS; SYMPTOMS
Optional Information
- Notes
- 14 refs., 3 figs., 1 tab.