Published April 1, 1995
| Version v1
Journal article
Fast DNA analysis by laser mass spectrometry for human genome analysis
- 1. Health Sciences Research Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6378 (United States)
- 2. Cooperative Ward-Laboratory, Chinese Academia Sinica, Taipei, Taiwan (China)
Description
Fast DNA sequencing by laser mass spectrometry is possible if the following 3 criteria are met: (1) Size of DNA fragment should be greater than 300 nucleotides. (2) Enough sensitivity to detect DNA produce from polymerases chain reactins (PCR). (3) Higher resolution of mass spectr. So far, the firt 2 criteria are met: If the resolution can be significantly improve, fast DNA sequencing by laser mass spectrometry weil be a reality in the near feature
Additional details
Identifiers
- DOI
- 10.1063/1.47557;
Publishing Information
- Journal Title
- AIP Conference Proceedings
- Journal Volume
- 329
- Journal Issue
- 1
- Journal Page Range
- p. 59-64
- ISSN
- 0094-243X
- CODEN
- APCPCS
Conference
- Title
- 7. international symposium on resonance ionization spectroscopy
- Dates
- 3-8 Jul 1994
- Place
- Bernkastel-Kues (Germany)
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 40032327
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- DNA; DNA SEQUENCING; HUMAN POPULATIONS; LASER RADIATION; NUCLEOTIDES; POLYMERASE CHAIN REACTION; POLYMERASES; QUANTITATIVE CHEMICAL ANALYSIS; RESOLUTION; RESONANCE IONIZATION MASS SPECTROSCOPY; SENSITIVITY
- Descriptors DEC
- CHEMICAL ANALYSIS; ELECTROMAGNETIC RADIATION; ENZYMES; GENE AMPLIFICATION; MASS SPECTROSCOPY; NUCLEIC ACIDS; NUCLEOTIDYLTRANSFERASES; ORGANIC COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; POPULATIONS; PROTEINS; RADIATIONS; SPECTROSCOPY; STRUCTURAL CHEMICAL ANALYSIS; TRANSFERASES
Optional Information
- Contract/Grant/Project number
- Contract no. AC05-84OR21400
- Notes
- (c) 1995 American Institute of Physics