Influence of percutaneous atherectomy together with ozone injection on the serum 6-keto-PGE1α and M-ENK levels in treating patients with lumbar disc protrusion

Objective: To investigate the influence of percutaneous atherectomy combined with ozone injection on the serum 6-keto-PGE1α and M-ENK levels in treating patients with lumbar disc protrusion. Methods: Based on random number table method, a total of successive 90 patients with lumbar disc protrusion were randomly divided into group A (n = 30, percutaneous atherectomy plus ozone injection), group B (n = 30, ozone injection) and group C (n = 30, percutaneous atherectomy). The serum 6-keto-PGE1α and M-ENK levels in all patients were determined before and after the treatment. Results: After the treatment, the serum 6-keto-PGE1α level showed a declining tendency, while the serum M-ENK level was elevated in all the three groups. The above changes in serum 6-keto-PGE1α and M-ENK levels were more significant in group A than those in group B and group C (P < 0.01). Significant difference in serum 6-keto-PGE1α and M-ENK levels existed between group B and group C (P < 0.05). Conclusion: In treating patients with lumbar disc protrusion, percutaneous atherectomy combined with ozone injection has benign regulation effect on the serum 6-keto-PGE1α and M-ENK levels, and this effect may be one of its therapeutic mechanisms for lumbar disc protrusion. (authors)