Published March 2018
| Version v1
Journal article
Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response
Creators
- 1. Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool (United Kingdom)
- 2. Gray Laboratories, Cancer Research UK/Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford (United Kingdom)
- 3. The National Eye Proton Therapy Centre, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington (United Kingdom)
Description
To investigate the precise mechanism of recognition and processing of ionizing radiation (IR)-induced complex DNA damage (CDD), where two or more DNA lesions are in close proximity, in cellular DNA which is packaged with histones to form chromatin.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.ijrobp.2017.11.012Additional details
Identifiers
- DOI
- 10.1016/j.ijrobp.2017.11.012;
- PII
- S0360301617341007;
Publishing Information
- Journal Title
- International Journal of Radiation Oncology, Biology and Physics
- Journal Volume
- 100
- Journal Issue
- 3
- Journal Page Range
- p. 776-784
- ISSN
- 0360-3016
- CODEN
- IOBPD3
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 52123569
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ALPHA PARTICLES; DNA DAMAGES; HISTONES; LET; PROTON BEAMS
- Descriptors DEC
- BEAMS; CHARGED PARTICLES; ENERGY TRANSFER; IONIZING RADIATIONS; NUCLEON BEAMS; ORGANIC COMPOUNDS; PARTICLE BEAMS; PROTEINS; RADIATIONS
Optional Information
- Copyright
- Copyright (c) 2017 The Authors. Published by Elsevier Inc.