Published January 2010
| Version v1
Journal article
Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals
Creators
- 1. Hashemite University, Zarka (Jordan). Chemistry Department, Faculty of Science
- 2. Tuebingen Universitaet, Tuebingen (Germany). Radiopharmazie, PET-Zentrum
- 3. Yarmouk University, Irbid (Jordan). Chemistry Department, Faculty of Science
- 4. Tuebingen Universitaet, Tuebingen (Germany). Interfakultaeres Institut fuer Biochemie
Description
The synthesis of the three 18F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Radioanalytical and Nuclear Chemistry
- Journal Volume
- 283
- Journal Issue
- 1
- Journal Page Range
- p. 239-243
- ISSN
- 0236-5731
- CODEN
- JRNCDM
INIS
- Country of Publication
- Hungary
- Country of Input or Organization
- Hungary
- INIS RN
- 41028645
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANOXIA; DRUGS; IMIDAZOLES; LABELLING; OXIMES
- Descriptors DEC
- AMINES; AZOLES; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS
Optional Information
- Notes
- 15 refs.