Early impact of cryosurgery ablation on the function of T cellular immunity in tumor-bearing rabbits

Objective: To discuss the early impact of cryosurgery ablation on the function of T cellular immunity in tumor-bearing rabbits through observing the changes of T cell subsets after cryosurgery procedure in experimental rabbits. Methods: (1) Thirty tumor-bearing rabbits were randomly and equally divided into 3 groups: group A, receiving cryosurgical treatment; group B, receiving surgical resection; and group C, used as control group. (2) Both the preoperative and the postoperative peripheral blood T cell subsets were determine in all experimental rabbits of three groups, the results were compared and statistically analyzed. Results: After the procedure, CD8 was significantly decreased in all three groups (P < 0.05). CD4 showed an obvious increase in group A (P < 0.05), while a marked decrease in both group B and group C (P < 0.05). The ratio of CD4 /CD8 showed a distinct elevation in group A (P < 0.05), while no change in both group B and group C. Conclusion: The results of this study indicates that cryosurgical ablation is superior to the surgical resection in enhancing the early effect of cell-mediated immunity. (authors)