Published 1984 | Version v1
Journal article Metadata-only

Chemical and physical parameters affecting the performance of the Os-191/Ir-191m generator

Creators

  • 1. Harvard Medical School, Boston, MA

Description

The development of an Os-191/Ir-191m generator suitable for radionuclide angiography in humans has elicited much interest. This generator employs [OsO2Cl4]2- on AG MP-1 anion exchange resin with a Dowex-2 scavenger column and is elute with normal saline at pH 1. The parent Os species is, however, neither well-defined nor homogeneous leading to less than optimal breakthrough of Os-191 (5 x 10-3%) and modest Ir-191m yield (10-15%). The effect of a range of parameters on generator performance has been evaluated as has been the way in which the assembly and loading process affects generator performance. In addition, a number of potential alternative generator systems have been evaluated. 11 references, 2 figures, 8 tables

Additional details

Publishing Information

Journal Title
ACS Symp. Ser.
Journal Issue
no.241
Series
ACS Symp. Ser.
ISSN
0097-6156
CODEN
ACSMC

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
17068755
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
DIAGNOSTIC TECHNIQUES; IRIDIUM 191; OSMIUM 191; PERFORMANCE; PRODUCTION; RADIOISOTOPE GENERATORS; SPECIFICATIONS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERNAL CONVERSION RADIOISOTO; IRIDIUM ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; OSMIUM ISOTOPES; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; STABLE ISOTOPES