Published April 2011
| Version v1
Journal article
Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporter
- 1. Pohang University of Science and Technology, Pohang (Korea, Republic of)
Description
The biotin-attached G8 molecular transporter (5) was synthesized and used together with quantum dots in preparing the complexes (QD-MT). The QD-MT complexes were studied in terms of the cellular uptake and the internalization mechanism in live HeLa cells with the aid of various known endocytosis inhibitors. It has been concluded that the QD-MT complex is internalized largely by macropinocytosis. The mouse tissue distribution of the QD-MT complex by i.p. and i.v. routes showed some organ selectivity and a good ability to cross the BBB
Additional details
Publishing Information
- Journal Title
- Bulletin of the Korean Chemical Society
- Journal Volume
- 32
- Journal Issue
- 4
- Series
- 21 refs, 10 figs
- Journal Page Range
- p. 1282-1292
- ISSN
- 0253-2964
INIS
- Country of Publication
- Korea, Republic of
- Country of Input or Organization
- Korea, Republic of
- INIS RN
- 48087198
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- ANIMAL TISSUES; MICE; MOLECULAR STRUCTURE; QUANTUM DOTS; UPTAKE
- Descriptors DEC
- ANIMALS; BODY; MAMMALS; NANOSTRUCTURES; RODENTS; VERTEBRATES