Specific delivery of mitomycin C to the liver, spleen and lung
- 1. Kyoto Univ. (Japan). Faculty of Pharmaceutical Science
Description
Gelatin spherical carriers of different sizes, nanospheres (NS) with a mean diameter of 280 nm and microspheres (MS) with a mean diameter of 14.9 μm, were prepared and their potential as delivery systems for anticancer agents was evaluated. Carriers were labeled with 131I and their biodistribution showed a selective distribution of [131I]NS to the liver and spleen, and [131I]MS to the lung. Incorporation of mytomycin C (MMC) as a free form followed the distribution pattern of the carriers alone, but as a dextran conjugate (MMCD) induced a sustained localization; with a slight decrease of the antitumor activity. Thus, this new formulation provided a very specific delivery system of MMC to the reticuloendothelial system and the lung with sustained localization. (Auth.)
Additional details
Additional titles
- Subtitle (English)
- Nano- and microspherical carriers of gelatin
Publishing Information
- Journal Title
- Int. J. Pharm.
- Journal Volume
- 8
- Journal Issue
- 2
- Series
- Int. J. Pharm.
- Journal Page Range
- 131-141
- ISSN
- 0378-5173
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 13650269
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- GELATIN; INTRAVENOUS INJECTION; IODINE 131; LABELLED COMPOUNDS; LIVER; LUNGS; MITOMYCIN; RADIONUCLIDE KINETICS; SPLEEN; UPTAKE
- Descriptors DEC
- ANTIBIOTICS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COLLOIDS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISPERSIONS; DRUGS; GLANDS; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RESPIRATORY SYSTEM