Identification Of Molecular Structures Of Normal And Pathological Human Breast Tissue Using Synchrotron Radiation

Scattering profiles of human breast tissues were measured by x-ray diffraction using a synchrotron radiation source in order to identify their structural features at molecular level (0.70≤q≤70.55 nm-1). Several parameters were extracted from these scattering profiles and statistically assessed using discriminant analysis. From this analysis, only the ratio between the peak intensities at q = 19.8 nm-1 and at q = 13.9 nm-1, as well as the FWHM were statistically significant and allowed distinguishing the human breast tissues with high accuracy, mainly for benign samples where it was found values of sensitivity and specificity of 100%.