Published April 1986 | Version v1
Journal article Metadata-only

Noncirrhotic portal fibrosis after Wilms' tumor therapy

Creators

  • 1. Vanderbilt Univ. Medical Center, Nashville, TN

Description

A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy

Additional details

Publishing Information

Journal Title
Gastroenterology
Journal Issue
no.4
Series
Gastroenterology.
ISSN
0016-5085
CODEN
GASTA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
17072360
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
DELAYED RADIATION EFFECTS; ESOPHAGUS; FIBROSIS; HEMORRHAGE; LIVER; NEOPLASMS; RADIATION EFFECTS; RADIATION INJURIES; RADIOTHERAPY; SIDE EFFECTS; VEINS
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DIGESTIVE SYSTEM; DISEASES; GLANDS; INJURIES; MEDICINE; ORGANS; PATHOLOGICAL CHANGES; SYMPTOMS; THERAPY