Published August 2007 | Version v1
Miscellaneous Metadata-only

Development of 188Re-HEDP as radiopharmaceutical for palliative bone pain

Creators

  • 1. Research and Development Section, Thailand Institution of Nuclear Technology, Bangkok (Thailand)
  • 2. Isotope Center, Thailand Institution of Nuclear Technology, Bangkok (Thailand)

Description

Full text: The optimized condition for labeling HEDP with Re-188 was assessed by wet labeling. The mixture solution of 10 mg HEDP, 3 mg SnCl2.2H2O, 4 mg Gentisic acid and 50 ?g of NH4ReO4 was labeled with 3- 10 mCi ReO-4 at pH1 with heating temperature at 100 ?C for 15 minutes. After adjusting pH to 5-6 with 0.3 M NaOAc pH 8 and NaOH, radiochemical purity of the labeled product was checked by TLC. Labeling efficiency was high as 98.88%. The HEDP ligand was prepared in form of lyophilized kits then labeled and controlled for labeling efficiency. Labeling yield of labeled HEDP kits were more than 94% for 5 months storage. Biodistribution of 188Re-HEDP in rat measured in % injected dose/g of bone at time 2, 4 and 24 hours was 1.372%, 1.302% and 1.154%, respectively

Availability note (English)

Available in abstract form only, full text entered in this record. Available from Thailand Institute of Nuclear Technology, Bangkok (Thailand)

Additional details

Publishing Information

Imprint Pagination
10 p.
Report number
INIS-TH--170

Conference

Title
10. Conference on Nuclear Science and Technology
Dates
16-17 Aug 2007
Place
Bangkok (Thailand)

INIS

Country of Publication
Thailand
Country of Input or Organization
Thailand
INIS RN
40048212
Subject category
S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Conference, Numerical Data, Non-conventional Literature
Descriptors DEI
EXPERIMENTAL DATA; LABELLED COMPOUNDS; LABELLING; LIGANDS; NEOPLASMS; RADIOPHARMACEUTICALS; RATS; RHENIUM 188; SKELETON
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DATA; DISEASES; DRUGS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUMERICAL DATA; ODD-ODD NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RHENIUM ISOTOPES; RODENTS; VERTEBRATES

Optional Information

Secondary number(s)
NST--10-MS02