Heating ability of La–Sr–Mn–Cu perovskite spheres under an alternating current magnetic field for magnetic hyperthermia mediators

La0.666Sr0.373Mn0.943Cu0.018O3 spheres (average diameter: 2.4 mm) were used as magnetic hyperthermia mediators. They were prepared by the polymerized complex method and alginate gelation. A starch paste containing nine such spheres (0.1034 g) was maintained at a constant temperature when it was exposed to an alternating current magnetic field (frequency: 1 MHz; magnetic field strength: 20–55 Oe-rms). After exposure to a magnetic field with a field strength of 55 Oe-rms for 60 min, a temperature of T60=73.5 °C was obtained. T60 for field strengths of 40 and 55 Oe-rms differed by only 2.6 °C. La0.666Sr0.373Mn0.943Cu0.018O3 spheres satisfy the following important requirements for heating mediators: their amount can be controlled in tumors, their temperature can be controlled without monitoring, and their heating ability is independent of the field strength and direction. Thus, La0.666Sr0.373Mn0.943Cu0.018O3 spheres are promising heating mediators for inducing magnetic hyperthermia. - Highlights: ► We prepared La–Sr–Mn–Cu perovskite spheres used as magnetic hyperthermia mediators. ► Our perovskite spheres were maintained at a constant temperature under AC field. ► The heating ability is independent of the field strength and direction.