Positron emission tomography and computed tomography assessments of the aging human brain
Creators
- 1. New York Univ. Medical Center, NY
Description
The relationship between alterations in brain structure and brain function was studied in vivo in both young and elderly human subjects. Computed tomography revealed significant age-related ventricular and cortical sulcal dilatation. The cortical changes were most closely related to age. Positron emission tomography failed to show regional changes in brain glucose metabolic rate. The results suggest that the normal aging brain undergoes structural atrophic changes without incurring regional metabolic changes. Examination of the correlations between the structural and the metabolic measures revealed no significant relationships. These data are discussed with respect to the significant structure-function relationships that have been reported in Alzheimer disease. 27 references, 3 figures, 2 tables
Additional details
Publishing Information
- Journal Title
- J. Comput. Assist. Tomogr.
- Journal Volume
- 8
- Journal Issue
- 1
- Series
- J. Comput. Assist. Tomogr.
- Journal Page Range
- 88-94
- ISSN
- 0363-8715
- CODEN
- JCATD
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17072869
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- AGING; ATROPHY; BRAIN; DYNAMIC FUNCTION STUDIES; EXPERIMENTAL DATA; GLUCOSE; IN VIVO; METABOLISM; POSITRON COMPUTED TOMOGRAPHY
- Descriptors DEC
- ALDEHYDES; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DATA; DISEASES; EMISSION COMPUTED TOMOGRAPHY; HEXOSES; INFORMATION; MONOSACCHARIDES; NERVOUS SYSTEM; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; SACCHARIDES; TOMOGRAPHY