Published 2021 | Version v1
Book Metadata-only

Sequence-dependent hydration water dynamics of dodecameric DNA

Creators

  • 1. Japan Atomic Energy Agency, Materials Science Research Center, Tokai, Ibaraki (Japan)
  • 2. National Institutes for Quantum and Radiological Science and Technology, Institute for Quantum Life Science, Kizugawa, Kyoto (Japan)
  • 3. Japan Atomic Energy Agency, J-PARC Center, Tokai, Ibaraki (Japan)
  • 4. Sumitomo Rubber Industries, Ltd., Research & Development HQ., Kobe, Hyogo (Japan)
  • 5. Nara Institute of Science and Technology, Ikoma, Nara (Japan)

Description

Hydration water dynamics were measured by quasi-elastic neutron scattering with H2O/D2O contrast for two DNA dodecamers, 5'CGCGAATTCGCG'3 and 5'CGCGTTAACGCG'3, which have been computationally shown to be structurally rigid and flexible, respectively. The dynamical transitions of the hydration water as well as DNA were observed for both sequences at approximately 240 K. Above the transition temperature, the mean square displacements of the hydration water for the rigid sequence were smaller than those for the flexible one. Furthermore, the relaxation time of the hydration water was longer in the rigid DNA than in the flexible DNA. We suggest that hydration water dynamics on the picosecond timescale are associated with sequence-dependent deformability of DNA. (author)

Availability note (English)

Available from DOI: https://doi.org/10.7566/JPSCP.33.011101
Part of:
Proceedings of the 3rd J-PARC Symposium (J-PARC2019)

Additional details

Identifiers

DOI
10.7566/JPSCP.33.011101;

Publishing Information

Publisher
Physical Society of Japan
Imprint Place
Tokyo (Japan)
ISBN
978-4-89027-146-7
Imprint Title
Proceedings of the 3rd J-PARC Symposium (J-PARC2019)
Imprint Pagination
[934 p.]
Journal Page Range
p. 011101.1-01110.6

Conference

Title
3. J-PARC symposium
Acronym
J-PARC2019
Dates
23-27 Sep 2019
Place
Tsukuba, Ibaraki (Japan)

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
53064323
Subject category
S60: APPLIED LIFE SCIENCES; S43: PARTICLE ACCELERATORS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ACCELERATOR EXPERIMENTAL FACILITIES; DNA; DNA SEQUENCING; ENERGY RESOLUTION; HYDRATION; INCOHERENT SCATTERING; J-PARC; POTASSIUM CHLORIDES; PROTEINS; QUASI-ELASTIC SCATTERING; RELAXATION TIME; SCATTERING LENGTHS; STRUCTURE FACTORS; TRANSITION TEMPERATURE; WATER
Descriptors DEC
ALKALI METAL COMPOUNDS; CHLORIDES; CHLORINE COMPOUNDS; DIMENSIONLESS NUMBERS; DIMENSIONS; DIRECT REACTIONS; HALIDES; HALOGEN COMPOUNDS; HYDROGEN COMPOUNDS; LENGTH; NUCLEAR REACTIONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; PHYSICAL PROPERTIES; POTASSIUM COMPOUNDS; POTASSIUM HALIDES; QUASI-FREE REACTIONS; RESOLUTION; SCATTERING; SOLVATION; STRUCTURAL CHEMICAL ANALYSIS; THERMODYNAMIC PROPERTIES

Optional Information

Notes
15 refs., 4 figs.