Deposition and retention of inhaled aggregate 67Ga2O3 particles in beagle dogs, Fischer-344 rats, and CD-1 mice
- 1. Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM
Description
Deposition and retention of inhaled 67Ga2O3 aerosols were measured in ten beagle dogs to provide reasonable estimates for human deposition and in Fischer-344 rats and Cd-1 mice to estimate lung burdens in small animals frequently used in toxicological evaluations. Aggregated particles of 67Ga2O3, 0.1 μm mass median diameter (MMD), were produced using heat treatment of 67Ga tetramethylheptanedione. Whole-body counting and gamma camera imaging were used to measure deposition. Pulmonary deposition in dogs was measured as 25% of the inhaled particles of the 0.1 μm particles. Tracheobronchial and nasopharyngeal deposition were much lower, 7% and 7% respectively. Pulmonary deposition of 0.1 μm (MMD) particles was calculated as 10% and 11% of inhaled particles in Fischer-344 rats and 15 and 20% in mice for two separate nose-only exposures of each species
Additional details
Publishing Information
- Journal Title
- Am. Ind. Hyg. Assoc. J.
- Journal Volume
- 45
- Journal Issue
- 6
- Series
- Am. Ind. Hyg. Assoc. J.
- Journal Page Range
- 377-381
- ISSN
- 0002-8894
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16077542
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- AEROSOLS; BEAGLES; BIOLOGICAL MODELS; BRONCHI; EXPERIMENTAL DATA; GALLIUM OXIDES; GALLIUM 67; GAMMA CAMERAS; INHALATION; LUNGS; MICE; PARTICLE SIZE; PARTICLES; PHARYNX; RADIONUCLIDE KINETICS; RATS; RETENTION; TISSUES; WHOLE-BODY COUNTING
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CAMERAS; CHALCOGENIDES; COLLOIDS; COUNTING TECHNIQUES; DATA; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISPERSIONS; DOGS; ELECTRON CAPTURE RADIOISOTOPES; GALLIUM COMPOUNDS; GALLIUM ISOTOPES; INFORMATION; INTAKE; INTERMEDIATE MASS NUCLEI; ISOTOPES; KINETICS; MAMMALS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANS; OXIDES; OXYGEN COMPOUNDS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; SIZE; SOLS; VERTEBRATES