Effects of gamma radiation and menadione (vit. K3) on dissolution and dimerization of δ-tocopherol

Effect of ionizing radiation and menadione (vit. K3) on dissolution and dimerization of δ-tocopherol was studied. Mixture of δ-tocopherol and menadione (vit. K3) dissolved in benzene, ethanol or used in substantia were irradiated at 2.5, 5, 10, 20 kGy dose using Co-60 as a radiation source. Dissolution of δ-tocopherol in substantia was lower then disintegration of δ-tocopherol dissolved in benzene or in ethanol. However, we did not observe any significant difference between dissolution of δ-tocopherol in both studied solvents. The number of formed dimers of δ-tocopherol were different for all three cases tested. The quantities of δ-tocopherol dimers were dependent on radiation dose. (author)