The callosal-septal interface lesion in multiple sclerosis: effect of sequence and imaging plane

We examined the effect of imaging plane and sequence on the demonstration of lesions at the callosalseptal interface (CSI) by magnetic resonance imaging in 20 patients with known multiple sclerosis. Variable-echo(VE) T2- and proton density (PD) weighted images were performed in coronal axial and sagittal planes. Sagittal gradient echo (GE) T2- and PD-weighted images were also performed. Lesions at the CSI were seen in all patients and were all demonstrated on both sagittal and coronal VE images. Sagittal PD-weighted GE images were slightly less sensitive but showed good overall agreement with sagittal VE. Axial VE and sagittal T2-weighted GE images demonstrated CSI lesions poorly. (orig.)