Published June 1, 2019 | Version v1
Journal article Metadata-only

Miniature fluorescence molecular tomography (FMT) endoscope based on a MEMS scanning mirror and an optical fiberscope

Creators

  • 1. Department of Medical Engineering, University of South Florida, Tampa, FL (United States)
  • 2. Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL (United States)
  • 3. Department of Biomedical Engineering, University of Florida, Gainesville, FL (United States)
  • 4. Emory University, Department of Surgery, Atlanta, GA (United States)

Description

We present a novel FMT endoscope by using a MEMS scanning mirror and an optical fiberscope. The diameter of this highly miniaturized FMT device is only 5 mm. To our knowledge, this is the smallest FMT device we found so far. Several phantom experiments based on indocyanine green (ICG) were conducted to demonstrate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (ATF-PEG-IO-830) and were then imaged to further demonstrate the ability of this FMT endoscope for imaging small animals. (paper)

Availability note (English)

Available from http://dx.doi.org/10.1088/1361-6560/ab23b3

Additional details

Identifiers

DOI
10.1088/1361-6560/ab23b3;

Publishing Information

Journal Title
Physics in Medicine and Biology
Journal Volume
64
Journal Issue
12
Journal Page Range
[7 p.]
ISSN
0031-9155
CODEN
PHMBA7

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
52003884
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
EQUIPMENT; FLUORESCENCE; INDOCYANINE GREEN; MEMS; MIRRORS
Descriptors DEC
AROMATICS; AZAARENES; AZOLES; DYES; EMISSION; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; INDICATORS; INDOLES; LUMINESCENCE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PHOTON EMISSION; POLYCYCLIC AROMATIC HYDROCARBONS; PYRROLES; SULFONATES