Thyrotoxicosis.Clinical recommendations for diagnosis and treatment. Part 1

Currently submitted an increased rate of thyrotoxicosis, which is characterized by polyetiology, a variety of clinical manifestations and potential treatments. Appropriate treatment requires an accurate diagnosis and depends on the comorbidities and preferences of the patient. The aim of the study was to consider the pathogenesis, clinical picture and diagnosis of thyrotoxicosis.Purpose. To highlight the key points of clinical guidelines on thyrotoxicosis diagnosis and treatment provided by the American Thyroid Association and the American Association of Clinical Endocrinologists, US Endocrine Society dealing with diagnosis and treatment of thyroid diseases as well as the local clinical protocols of SO «Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine».Materials and methods. Based on the research in the electronic databases of last 5 years publications, which are included in the Cochrane Library, PUBMED and MEDLINE databases. Clinical guidelines are based on expert consensus and assessing the significance according to the international guideline of thyrotoxicosis.Conclusions. Thyrotoxicosis treatment remains a challenging issue of modern internal medicine. Despite the existing numerous clinically proven protocols for the treatment of this pathology, the comorbid background of patients complicates following them. The implementation of the provided protocol elements will make it possible to introduce the principles of a customized approach in thyrotoxicosis patients. (author)