Neutron dosimetry in radiotherapy: experimental study and Monte Carlo personalised dose calculation tool development
Description
Treatment optimization in radiotherapy aims at increasing the accuracy of cancer cell irradiation while saving the surrounding healthy organs. However, the peripheral dose deposited in healthy tissues far away from the tumour are currently not calculated by the treatment planning systems even if it can be responsible for radiation induced secondary cancers. Among the different components, neutrons produced through photo-nuclear processes are suffering from an important lack of dosimetric data. An experimental and Monte Carlo simulation study of the secondary neutron production in radiotherapy led us to develop an algorithm using the Monte Carlo calculation precision to estimate the 3D neutron dose delivered to the patient. Such a tool will allow the generation of dosimetric data bases ready to be used for the improvement of 'dose-risk' mathematical models specific to the low dose irradiation to peripheral organs occurring in radiotherapy. (author)
Abstract (French)
L'optimisation des traitements en radiotherapie vise a ameliorer la precision de l'irradiation des cellules cancereuses pour epargner le plus possible les organes environnants. Or la dose peripherique deposee dans les tissus les plus eloignes de la tumeur n'est actuellement pas calculee par les logiciels de planification de traitement, alors qu'elle peut etre responsable de l'induction de cancers secondaires radio-induits. Parmi les differentes composantes, les neutrons produits par processus photo-nucleaires sont les particules secondaires pour lesquelles il y a un manque important de donnees dosimetriques. Une etude experimentale et par simulation Monte Carlo de la production des neutrons secondaires en radiotherapie nous a conduit a developper un algorithme qui utilise la precision du calcul Monte Carlo pour l'estimation de la distribution 3D de la dose neutron delivree au patient. Un tel outil permettra la creation de bases de donnees dosimetriques pouvant etre utilisees pour l'amelioration des modeles mathematiques 'dose-risque' specifiques a l'irradiation des organes peripheriques a de faibles doses en radiotherapie. (auteur)
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Additional details
Additional titles
- Original title (French)
- Dosimetrie neutron en radiotherapie: etude experimentale et developpement d'un outil personnalise de calcul de dose Monte Carlo
Publishing Information
- Imprint Pagination
- 218 p.
- Report number
- FRNC-TH--13263
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 53094692
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Thesis
- Descriptors DEI
- COMPUTERIZED SIMULATION; CROSS SECTIONS; DIELECTRIC TRACK DETECTORS; G CODES; KERMA; KINETIC ENERGY; LINEAR ACCELERATORS; MEAN FREE PATH; MONTE CARLO METHOD; NEUTRON DETECTION; NEUTRON DOSIMETRY; NEUTRON SPECTRA; PHOTOEMISSION; PHOTON BEAMS; RADIOTHERAPY; RECOILS; SPATIAL DISTRIBUTION
- Descriptors DEC
- ACCELERATORS; BEAMS; CALCULATION METHODS; COMPUTER CODES; DETECTION; DISTRIBUTION; DOSIMETRY; EMISSION; ENERGY; MEASURING INSTRUMENTS; MEDICINE; NUCLEAR MEDICINE; RADIATION DETECTION; RADIATION DETECTORS; RADIOLOGY; SECONDARY EMISSION; SIMULATION; SPECTRA; THERAPY
Optional Information
- Notes
- 286 refs.; Available from the INIS Liaison Officer for France, see the INIS website for current contact and E-mail addresses