Pathomorphism of malignant tumors follOwing combination and complex therapy including hyperthermia

Some basic regularities of pathomorphism development in malignant tumors upon different variants of therapy using hyperthermic effects are characterized. The hyperthermia effect manifests in irreversible disorder of blood circulation and tissue structure of radioresistant and difficultly accessed for chemotherapy preparations of central neoplasm sections. Probably for this reason using radio- and chemotherapy combined with hyperthermia intensifies their antitumoral activity which is confirmed by the results of clynical and morphological investigations. Structural changes in a tumor tissue arising under the influence of these meods of therapy have not any specific peculiarities as compared with spontaneous regressive changes or signs of radial and drug pathomorphism. The prevalence of irreversible injuries of neoplasm tissue upon hyperthermia increases however and terms of their appearance are shorter than when using traditional methods of therapy. In connection with this the most convenient method of therapeutic efficiency estimation comprising hyperthermic effects may be the determination of the volume of necrotized tumor sites