A prospective study of long-term results and the red blood cell immune adherence function following 131I treatment of Graves' disease

Objective: To observe the long-term curative effect and red blood cell immune function in patients with Graves' Disease (GD) after radioactive iodine (131I) treatment. Methods: To observe the hyperthyroid symptoms, physical signs and to measure the concentration of FT3, FT4, FSH by radioimmunoassay, the percent of RBC-C3bR-YR(%), RBC-IC-YR(%). Results: Patients with GD treated by 131I after three month, these hyperthyroid symptoms, Physical signs are alleviated and even vanished in patients who were treated by 131I after 1.5 years, RBC-C3bR-YR(%) are normal in all patients, but RBC-IC-YR(%) are higher than before treatment with 131I, then become lower after three months, treatment by 131I but they were higher than those in normal group, when treated with 131I after 1.5 years, RBC-IC-YR(%) are normal, the relationship between RBC-C3bR-YR(%) and RBC-IC-YR(%) are positively interacted. Conclusion: The 131I treatment produces a good rapid curative effect for GD patients, the disorder state of the red cell immune adherence system is rapidly corrected and this effect is unidirectional. So RBC-C3bR-YR(%), RBC-IC-YR(%) are the useful predictors of GD remission and their relationship, RBC-IC-YR(%) are helpful in explaining the mechanism of radioactive iodine therapy and are the predictors of GD remission after 131I treatment