Published March 1981 | Version v1
Journal article Metadata-only

Suppressor cell activity following total lymphoid irradiation (TLI), bone marrow (BM) injection, and kidney transplantation in baboons

Creators

  • 1. Univ. of Witwatersrand, Johannesburg, South Africa

Description

Induction of specific tissue transplantation tolerance by fractionated TLI was first described in adult mice, rats, and dogs. The method was equally effective in inducing unresponsiveness in outbred baboons, and irradiation given in fractions was confirmed to be more efficient than single dose. This study investigated the cumulative effect of 600 to 2400 rad TLI on the immune response of baboons treated according to a schedule applicable to patients awaiting renal transplantation. The possible mechanisms involved in tolerogenesis include the following: broad nonspecific nonreactivity, clonal deletion, suppressor cell activity, and enhancement

Additional details

Publishing Information

Journal Title
Transplant. Soc., Int. Cong., Proc.
Journal Volume
13
Journal Issue
1
Series
Transplant. Soc., Int. Cong., Proc.
Journal Page Range
455-457

Conference

Title
8. international congress of the Transplantation Society.
Dates
5 Jul 1980.
Place
Boston, MA, USA.

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
12629358
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
APES; BIOLOGICAL RADIATION EFFECTS; BONE MARROW CELLS; FRACTIONATED IRRADIATION; IMMUNITY; IMMUNOSUPPRESSION; KIDNEYS; LYMPH NODES; LYMPHOCYTES; PARTIAL BODY IRRADIATION; SURVIVAL TIME; TRANSPLANTS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; EXTERNAL IRRADIATION; IRRADIATION; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; ORGANS; PRIMATES; RADIATION EFFECTS; SOMATIC CELLS; VERTEBRATES