Published August 1991
| Version v1
Journal article
Preparation and pre-clinical evaluation of radioiodinated IBZP
Creators
- 1. Nucl. Medicine Lab. of Ministry of Public Health, Wuxi (China)
Description
In developing new receptor-site specific brain imaging agents for SPECT, 131I-IBZP and 125I-IBZP: the D1 specific dopamine binding agent, were prepared. Carrier free 125I and 131I IBZP were labelled with the chloramine-T method. The radioactive and nonradioactive starting material could be separated from the desired product on HPLC. In vitro receptor binding test, in vivo rat biodistribution and SPECT imaging in monkey brain showed the radioiodinated IBZP binds with high affinity to specific D1 receptor binding sites in the striatum of the rat and monkey. These preliminary date indicated that this agent may be utilized to investigate the D1 receptors in human
Additional details
Additional titles
- Subtitle (English)
- A potential CNS dopamine D1 receptor imaging agent
Publishing Information
- Journal Title
- Chinese Journal of Nuclear Medicine
- Journal Volume
- 11
- Journal Issue
- 3
- Journal Page Range
- p. 177-180.
- ISSN
- 0253-9780
- CODEN
- CITCDE
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 24004999
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CENTRAL NERVOUS SYSTEM; CHEMICAL PREPARATION; CONTRAST MEDIA; DOPAMINE; IODINE 131; LABELLED COMPOUNDS; LABELLING; RECEPTORS
- Descriptors DEC
- AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; DAYS LIVING RADIOISOTOPES; DRUGS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PHENOLS; POLYPHENOLS; RADIOISOTOPES; SYMPATHOMIMETICS; SYNTHESIS