Published December 1975 | Version v1
Journal article

Interval effect of β-irradiation and subsequent 4-nitroquinoline 1-oxide painting on skin tumor induction in mice

  • 1. National Cancer Center Research Inst., Tokyo

Description

Skin tumors were produced in female ICR mice by 90Sr--90Y β-irradiation and subsequent 4-nitroquinoline 1-oxide painting. The doses were chosen so as to produce no tumors with a single agent alone; the interval between two treatments ranged from 11 to 408 days. The tumor induction rate was found to be at almost the same level (average, 12.4%) for each interval. The results indicate the persistence of the latent carcinogenic alterations in the β-irradiated mouse skin

Additional details

Publishing Information

Journal Title
Cancer Res.
Journal Volume
35
Journal Issue
12
Series
Cancer Res.
Journal Page Range
3663-3666