Low doses and problems of synergistic interaction of environmental factors

Methodology approach demonstrating a principle importance of mutual increase in damaging action of physical and chemical environmental factors at low doses and intensities of ionizing radiation was described. A generalize conceptual basis of synergism was suggested which was appropriate both for combined action of ionizing radiation with other agents and for combined action of any other hazardous environmental factors. It was shown theoretically that there was available the optimal ratio of damages induced by acting agents under which the highest synergism was obtained. The results presented had of principle importance for interpretation of the high effectiveness of low dose and dose rate of ionizing radiation observed in some cases