Published 1998 | Version v1
Book Metadata-only

Automated production of no carrier added Holmium-166

Creators

  • 1. Australian Nuclear Science and Technology Organisation (Australia)
  • 2. Oak Ridge National Laboratory (United States)

Description

Holmium-166 (166Ho) is used in radiotherapeutic applications such as radio-immunospecific pharmaceuticals, bone marrow ablation and radiation synovectomy and can be produced with moderate specific activity by the 165Ho[n,γ166Ho reaction. Higher specific activity carrier-free 166Ho can be obtained from the decay of dysprosium-166 (166Dy), produced by the double neutron capture reaction 164Dy[n.γ]165Dy[n,γ]166Dy. 166Ho can be separated from 166Dy by reverse phase ion exchange chromatography in high radionuclidic purity. An automated system has been developed to process the irradiated dysprosium oxide (Dy2O3) targets, carry out HPLC separation and deliver 166Ho in a form suitable for radiolabelling proteins and pharmaceuticals. (author)

Availability note (English)

Available from Canadian Nuclear Society, 144 Front Street, Suite 475, Toronto, ON M5J 2L7, Canada
Part of:
Proceedings of the 11th Pacific Basin Nuclear Conference

Additional details

Publishing Information

Publisher
Canadian Nuclear Society
Imprint Place
Toronto, ON (Canada)
ISBN
0-919784-55-0
Imprint Title
Proceedings of the 11th Pacific Basin Nuclear Conference
Imprint Pagination
2 v.
Journal Page Range
v. 1 p. 761-765

Conference

Title
11. Pacific Basin Nuclear Conference. International co-operation in the Pacific Rim for the 21st century
Dates
3-7 May 1998
Place
Banff, Alberta (Canada)

INIS

Country of Publication
Canada
Country of Input or Organization
Canada
INIS RN
32000278
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CARRIER-FREE ISOTOPES; HOLMIUM 166; NEUTRON ACTIVATION ANALYSIS; NUCLEAR MEDICINE; RADIOISOTOPES; RADIOTHERAPY
Descriptors DEC
ACTIVATION ANALYSIS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL ANALYSIS; DAYS LIVING RADIOISOTOPES; HOLMIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; RADIOLOGY; RARE EARTH NUCLEI; THERAPY; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
15 refs., 1 tab.