Published May 2006 | Version v1
Journal article Metadata-only

Ion Channel Conductance Measurements on a Silicon-Based Platform

Creators

  • 1. Arizona State University, Center for Solid State Electronics Research, Tempe, AZ 85287 (United States)
  • 2. Worcester Polytechnic Institute, Department of Electrical and Computer Engineering, Worcester, MA 01609 (United States)
  • 3. Rush Medical College, Department of Molecular Biophysics and Physiology, Chicago, IL 60612 (United States)
  • 4. Illinois Institute of Technology, Department of Electrical and Computer Engineering, Chicago, IL 60616 (United States)

Description

Conductance measurements of the transmembrane porin protein OmpF as a function of pH and bath concentration have been made with both a microfabricated silicon substrate device and a commercially available polystyrene aperture. Ion transport through the channel was simulated in atomic detail: the measured current was compared with theoretically calculated current, using a Brownian Dynamics kernel coupled to the Poisson equation by a P3M force field. The explicit protein structure and fixed charge distribution in the protein are calculated using the molecular dynamics code, GROMACS. Reasonable agreement is obtained in the simulated versus measured conductance over the range of experimental concentrations studied

Availability note (English)

Available online at http://stacks.iop.org/1742-6596/38/21/jpconf6_38_006.pdf or at the Web site for the Journal of Physics. Conference Series (Online) (ISSN 1742-6596) http://www.iop.org/

Additional details

Identifiers

URL
http://stacks.iop.org/1742-6596/38/21/jpconf6_38_006.pdf; http://www.iop.org/;
DOI
10.1088/1742-6596/38/1/006;

Publishing Information

Journal Title
Journal of Physics. Conference Series (Online)
Journal Volume
38
Journal Issue
1
Journal Page Range
p. 21-24
ISSN
1742-6596

Conference

Title
7. international conference on new phenomena in mesoscopic structures; 5. international conference on surfaces and interfaces of mesoscopic devices
Dates
27 Nov - 2 Dec 2005
Place
Maui, HI (United States)

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
38028614
Subject category
S75: CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CHARGE DISTRIBUTION; ELECTRIC CURRENTS; IONIC CONDUCTIVITY; IONS; KERNELS; MOLECULAR DYNAMICS METHOD; PH VALUE; POISSON EQUATION; POLYSTYRENE; PROTEIN STRUCTURE; PROTEINS; SILICON; SUBSTRATES
Descriptors DEC
CALCULATION METHODS; CHARGED PARTICLES; CURRENTS; DIFFERENTIAL EQUATIONS; ELECTRIC CONDUCTIVITY; ELECTRICAL PROPERTIES; ELEMENTS; EQUATIONS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC POLYMERS; PARTIAL DIFFERENTIAL EQUATIONS; PETROCHEMICALS; PETROLEUM PRODUCTS; PHYSICAL PROPERTIES; PLASTICS; POLYMERS; POLYOLEFINS; POLYVINYLS; SEMIMETALS; SYNTHETIC MATERIALS