Effect of some radio-modifying preparations on the doses absorbed by the thyroid glands in orally introduced iodine-131

In order to estimate the reduction dose rates of J131 absorbed by thyroid glands after preliminary administration of several chemical protectors, the experiments on 210 male Wistar rats were carried out. The protectors AET, VVR-2721, cysteamine hydrochloride, serotonin, creatine sulfate and Adeturon were applied intraperitoneally and after different periods of time J131 was introduced via stomach sounding . The results were shown as measured absorbed doses as well as calculated thyroid gland protection coefficients (PC). In all cases a sharp reduction of the absorbed doses in the first minutes after applications was found. The maximum PC of about 50-55% for serotonin, cysteamine and VVR-2721 was obtained. The protection effect gradually died down in the longer periods of time and practically it was missing in all cases in the 24th hour. The protection effect of radioprotectors was evaluated as unessential even in the most favourable cases