Published August 8, 2012 | Version v1
Journal article Metadata-only

A case–control study of occupation/industry and renal cell carcinoma risk

Creators

  • 1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, MSC 7242, Bethesda, MD 20892-7242 (United States)
  • 2. Wayne State University, Karmanos Cancer Institute, 110 E. Warren, Detroit, MI, 48201 (United States)
  • 3. University of Illinois, 877 SPHPI M/C 923, 1603 W. Taylor Street, Chicago, IL, 60612 (United States)
  • 4. Formerly of Information Management Service Inc, 6110 Executive Blvd Suite #310, Rockville, MD, 20852 (United States)
  • 5. Formerly of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD (United States)
  • 6. Stewart Exposure Assessments, LLC, Arlington, VA (United States)

Description

The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC). Between 2002 and 2007, a population-based case–control study of Caucasians and African Americans (1,217 cases; 1,235 controls) was conducted within the Detroit and Chicago metropolitan areas to investigate risk factors for RCC. As part of this study, occupational histories were ascertained through in-person interviews. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating occupation and industry to RCC risk using adjusted unconditional logistic regression models. Employment in the agricultural crop production industry for five years or more was associated with RCC (OR = 3.3 [95% CI = 1.0-11.5]) and ccRCC in particular (OR = 6.3 [95% CI = 1.7-23.3], P for trend with duration of employment = 0.0050). Similarly, RCC risk was elevated for employment of five years or longer in non-managerial agricultural and related occupations (ORRCC = 2.1 [95% CI = 1.0-4.5]; ORccRCC = 3.1 [95% CI = 1.4-6.8]). Employment in the dry-cleaning industry was also associated with elevated risk (ORRCC = 2.0 [95% CI = 0.9-4.4], P for trend = 0.093; ORccRCC = 3.0 [95% CI = 1.2-7.4], P for trend = 0.031). Suggestive elevated associations were observed for police/public safety workers, health care workers and technicians, and employment in the electronics, auto repair, and cleaning/janitorial services industries; protective associations were suggested for many white-collar jobs including computer science and administrative occupations as well employment in the business, legislative, and education industries. Our findings provide support for an elevated risk of RCC in the agricultural and dry-cleaning industries and suggest that these associations may be stronger for the ccRCC subtype. Additional studies are needed to confirm these findings

Availability note (English)

Available from http://dx.doi.org/10.1186/1471-2407-12-344; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502582

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502582;
DOI
10.1186/1471-2407-12-344;

Publishing Information

Journal Title
BMC cancer (Online)
Journal Volume
12
Journal Page Range
p. 344
ISSN
1471-2407

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
46111753
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CARCINOMAS; CHICAGO; COMPUTERS; EDUCATION; EMPLOYMENT; ETIOLOGY; HAZARDS; INDUSTRY; OCCUPATIONS; PERSONNEL; REPAIR; SAFETY
Descriptors DEC
DEVELOPED COUNTRIES; DISEASES; ILLINOIS; NEOPLASMS; NORTH AMERICA; URBAN AREAS; USA

Optional Information

Copyright
Copyright (c)2012 Karami et al.
Notes
PMCID: PMC3502582; PUBLISHER-ID: 1471-2407-12-344; PMID: 22873580; OAI: oai:pubmedcentral.nih.gov:3502582; licensee BioMed Central Ltd.