Biological studies on the effect of some Egyptian medicinal plants in irradiated rats

Various biological studies (toxicological, pharmacological biochemical and histopathological were carried out on Origanum Majorana and Artemisia herba alba ethanolic extracts. The acute toxicity study (LD50) revealed that both extracts are quietly safe. Both doses (0.25 and 0.5 g/kg b.wt.) of O. Majorana ethanolic extract showed a significant anti-inflammatory (acute and systemic) analgesic and mild anti-pyretic effect. Both doses (0.25 and 0.5 g/kg b.wt.) of A. herba alba ethanolic extract showed a significant anti-inflammatory (acute and systemic) analgesic and mild anti-pyretic effect. Moreover, histopathological findings of stomach and intestine of irradiated rats revealed that both doses of both extracts possess a gastrointestinal protective effect against radiation-induced gastritis and enteritis. Prolonged administration of both doses of both extracts for one month revealed that both doses of O. Majorana ethanolic extract possess a hepato protective and reno protective effect, while there was no significant effect of both doses of A. herba alba ethanolic extract on the biochemical parameters, but there were slight changes in liver and kidney on the histological level.