Published 1981
| Version v1
Miscellaneous
Effect of lead acetate or bismuth chloride and X-radiation on mortality and GOT, GPT, and O-demethylase activity of (white) mice
Description
The injection of 100 mg/kg body weight of lead acetate led to a temporarily advanced mortality induced by X-radiation. The corresponding advanced mortality due to bismuth chloride (250 mg/kg body weight) was only minor. In view of the activity presented by the SGOT and SGPT and of the O-demethylase of the liver, the impairing effects of lead acetate on the radiation injuries cannot be attributed to a hepatic damage. In cases of radiation damages an intensification of bacteriaemia due to lead acetate neither appears probable. Considering the mortality course we probably have to proceed from the supposition that lead acetate intensifies the radiation damage by reducing the endotoxine-detoxicant ability of the RES. (orig./MG)
Availability note (English)
Available from the library of Freiburg Univ. (Germany, F.R.).Abstract (German)
Die Injektion von 100 mg/kg Koerpergewicht Bleiacetat bewirkte eine zeitliche Vorverlagerung der strahlenbedingten Mortalitaet. Die entsprechende Vorverlagerung von Wismutchlorid (250 mg/kg Koerpergewicht) war gering. Gemessen an der Aktivitaet der SGOT und SGPT sowie der O-Demethylase der Leber kann die verschlechternde Wirkung von Bleiacetat auf die Strahlenkrankheit nicht auf eine Leberschaedigung zurueckgefuehrt werden. Ebenfalls ist eine Verstaerkung der Bakteriaemie durch Bleiacetat bei Strahlenschaedigung nicht wahrscheinlich. Am ehesten ist nach dem Mortalitaetsverlauf anzunehmen, dass Bleiacetat den Strahlenschaden ueber eine Minderung der Endotoxin-entgiftenden Faehigkeit des RES verstaerkt. (orig./MG)Additional details
Additional titles
- Original title (German)
- Die Wirkung von Bleiacetat, Wismutchlorid und Roentgenbestrahlung auf den Sterblichkeitsverlauf und auf die GOT-, GPT- und O-Demethylase-Aktivitaet bei (weissen) Maeusen
Publishing Information
- Imprint Pagination
- 54 p.
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 14783213
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Thesis, Non-conventional Literature
- Descriptors DEI
- ACETATES; AMINOTRANSFERASES; BIOLOGICAL EFFECTS; BISMUTH CHLORIDES; CATALYSIS; EXTERNAL IRRADIATION; INJECTION; LEAD COMPOUNDS; LETHAL IRRADIATION; LIVER; MICE; MORTALITY; RADIATION INJURIES; RADIATION SYNDROME; RESPONSE MODIFYING FACTORS; X RADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL RADIATION EFFECTS; BISMUTH COMPOUNDS; BODY; CARBOXYLIC ACID SALTS; CHLORIDES; CHLORINE COMPOUNDS; DIGESTIVE SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; ENZYMES; GLANDS; HALIDES; HALOGEN COMPOUNDS; INJURIES; INTAKE; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; TRANSFERASES; VERTEBRATES