Published 1975
| Version v1
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Reinvestigation of the preparation of 131I-4-iodoantipyrine from 131I-iodide
Description
123I-4-Iodoantipyrine (4-IAP) has been suggested as a radiopharmaceutical for direct imaging of regional cerebral perfusion. In routine clinical use, a reliable source of the labeled compound is required. Therefore, we chose to reinvestigate the preparation of 131I-4-IAP from 131I-iodide and unlabeled 4-IAP or 4-bromoantipyrine (4-BrAP) in acidic, aqueous solution. Using 4-IAP as starting material, quantitative yields (greater than or equal to 95 percent) of labeled 4-IAP are obtained with 5 min of heating at 1000C in the pH = 1.5 to 2.5 and free radioiodide can be removed by anion exchange. Mechanistic implications of the labeling kinetics are discussed
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Additional details
Publishing Information
- Imprint Pagination
- 15 p.
- Report number
- UCLA--12-1106
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 8309643
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANTIPYRINE; CHEMICAL REACTION KINETICS; IODINE 131; LABELLING; RADIOCHEMISTRY; RADIOPHARMACEUTICALS
- Descriptors DEC
- ANALGESICS; ANTIPYRETICS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMISTRY; DAYS LIVING RADIOISOTOPES; DRUGS; HETEROCYCLIC COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRAZOLES; PYRAZOLINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; REACTION KINETICS
Optional Information
- Notes
- Available from NTIS. $3.50.