Published January 1988
| Version v1
Journal article
Effect of N-methylformamide on radiocurability of murine tumors
Creators
- 1. Univ. of Texas, M. D. Anderson Hospital and Tumor Institute, Houston (USA)
Description
N-Methylformamide (NMF) is a polar solvent with maturational activity, i.e., it induces malignant cells to form more differentiated phenotypes. In addition, it renders tumor cells more sensitive to chemotherapeutic drugs and ionizing radiation. In the present study, NMF failed to augment radiocurability, as measured by the single-dose TCD50 assay, of two murine tumors: an 8-mm fibrosarcoma (FSA) and a 6-mm mammary carcinoma (MCA-K). NMF, at a dose of 300 mg/kg, was given ip daily for several days before and/or after local tumor irradiation
Additional details
Publishing Information
- Journal Title
- Radiat. Res.
- Journal Volume
- 113
- Journal Issue
- 1
- Series
- Radiat. Res.
- Journal Page Range
- 199-203
- ISSN
- 0033-7587
- CODEN
- RAREA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19062829
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANTINEOPLASTIC DRUGS; CARCINOMAS; CHEMOTHERAPY; EXPERIMENTAL NEOPLASMS; FIBROSARCOMAS; MICE; PHENOTYPE; RADIOSENSITIVITY; RADIOTHERAPY; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; DISEASES; DRUGS; MAMMALS; MEDICINE; NEOPLASMS; RODENTS; SARCOMAS; THERAPY; VERTEBRATES