Published April 2010 | Version v1
Journal article Metadata-only

Study on sensitivity of SX1 inbred-strain mice to radiation

Creators

  • 1. China Institute for Radiation Protection, Taiyuan (China)
  • 2. Department of Comparative Medicine, Shanxi Tumor Institute, Taiyuan (China)

Description

The study is to investigate the sensitivity of SXl inbred-strain mice to ionizing radiation and provide the background data for other radiation-related studies using SXl inbred-strain mice. LD50/30 of SXl inbred-strain mice and KM mice to 60Co γ rays and the changes of nucleated cell count in bone marrow, DNA content in bone marrow cells, CFU-S and WBC in peripheral blood following irradiated with different dose of γ rays were observed. The LD50/30 of SXl inbred-strain mouse to γ rays significantly lower than those of KM mice. After irradiated, the nucleated cell count in bone marrow and DNA content of bone marrow cells of SXl inbred-strain mice were lower and their recovery was slower than KM mice. The conclusion was, comparing with parent-KM mice, SXl inbred-strain mice has higher sensitivity to ionizing radiation. (authors)

Additional details

Publishing Information

Journal Title
Radiation Protection Bulletin
Journal Volume
30
Journal Issue
2
Journal Page Range
p. 14-17, 33
ISSN
1004-6356

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
50042260
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BLOOD; BONE MARROW CELLS; COBALT 60; COMPARATIVE EVALUATIONS; DNA; IONIZING RADIATIONS; IRRADIATION; MICE; RADIATION DOSES; SENSITIVITY; TOXICITY
Descriptors DEC
ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY FLUIDS; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; DOSES; EVALUATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIATIONS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
6 figs., 2 tabs., 3 refs.