Radiolabeling and biodistribution of 177Lu-DETMP and 177Lu-DOTMP

The labeling methods for 177Lu-EDTMP and 177Lu-DOTMP were established, and the biodistribution of 177Lu-EDTMP and 177Lu-DOTMP in normal mice was carried out as well. The optimal experimental condition of 177Lu-EDTMP and 177Lu-DOTMP was as follows: EDTMP 25 mg, 177LuCl3 solution 100 μL(12.8 MBq), pH 8 at 100 degree C for 30 min and DOTMP 6.3 mg, 177LuCl3 solution 100 μL (5 MBq), pH 9 at 100 degree C for 15 min respectively. Both of the two radiolabeled complex were observed to be good stability for 7 days at room temperature, the radiochemical purity was more than 98%. The results showed that 177Lu-EDTMP and 177Lu-DOTMP were selective skeletal uptake and mainly excreted by kidney. 177Lu-DOTMP was more quickly cleared from blood than 177Lu-EDTMP. It indicated that the two labeling compounds have good bone targeting. (authors)