Published October 2016 | Version v1
Journal article Metadata-only

Development of a specific 99mTc-MAG3-mAb-WF-AF-1 for noninvasive detection of Aspergillus fumigatus

Creators

  • 1. Shanghai Jiao Tong University School of Medicine, Shanghai (China). Department of Respiratory Medicine, Shanghai General Hospital
  • 2. Fudan University, Shanghai (China). Department of Nuclear Medicine, Zhongshan Hospital
  • 3. Fuyang People's Hospital, Fuyang, Anhui (China). Department of Respiratory Medicine
  • 4. Fudan University, Shanghai (China). Department of Respiratory Medicine, Huadong Hospital
  • 5. Fudan University, Shanghai (China). Department of Respiratory Medicine, Huashan Hospital

Description

Aspergillus species are ubiquitous fungi that can cause varieties of lung diseases. Early detection is critical for favorable outcomes. The feasibility of using a technetium-99m (99mTc)-labeled anti-Aspergillus (WF-AF-1) targeting the Aspergillus cell wall for the early detection of Aspergillusfumigatus in the lung was evaluated. In vitro binding study showed 99mTc-WF-AF-1 preferentially bound to A. fumigatus. Biodistribution and scintigraphy showed significant accumulation of radioactivity in A. fumigatus conidia-instilled lungs. This study demonstrated that 99mTc-WF-AF-1 directly targeting A. fumigatus may be valuable for early, noninvasive detection, and provides a referable strategy for the detection of other microorganisms. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
310
Journal Issue
1
Journal Page Range
p. 389-397
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
47118428
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ASPERGILLUS; BIOLOGICAL LOCALIZATION; IN VITRO; LUNGS; NONDESTRUCTIVE TESTING; RADIOPHARMACEUTICALS; TECHNETIUM 99; THERAPEUTIC USES
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DRUGS; EUMYCOTA; FUNGI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MATERIALS TESTING; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PLANTS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RESPIRATORY SYSTEM; TECHNETIUM ISOTOPES; TESTING; USES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
35 refs.